Study of weight loss medication for youth with hypothalamic obesity
Part of Brain & nervous system, Cancer, Genetic & congenital, Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests a combination of two medications, phentermine and topiramate, to see if they help young people with hypothalamic obesity lose weight safely. Hypothalamic obesity is rapid weight gain caused by injury to the hypothalamus, often from a brain tumor or its treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 6 and 28 years old.
- You gained weight quickly after a brain tumor or its treatment.
- You have obesity (BMI above the 95th percentile for your age and sex, or BMI over 30 for adults).
- You have evidence of hypothalamus injury on an MRI, and it's been at least 6 months since your last tumor treatment.
- You have been on a stable dose of any hormone replacement or appetite medications for at least 2 months.
- If you are a female who has started your period, you must use effective birth control or have confirmed hormone issues that prevent pregnancy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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