Study of Iguratimod for chronic graft-versus-host disease
Treatments studied
Part of Immune system & allergy clinical trials.
This trial tests an experimental drug called Iguratimod for people with chronic graft-versus-host disease (cGVHD) after a stem cell transplant. It aims to see if the drug can safely control cGVHD symptoms when other treatments haven't worked well enough.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and have had a stem cell transplant from a donor.
- You have chronic GVHD symptoms that need ongoing treatment.
- You have already tried between 1 and 5 different treatments for chronic GVHD.
- Your current steroid dose (like prednisone) has been stable for at least 2 weeks, or you've had trouble reducing it.
- You are able to take pills by mouth and do not have severe digestive problems.
- You are not pregnant or breastfeeding, and if you could become pregnant, you agree to use birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests two medications (belumosudil and ruxolitinib) together for chronic graft-versus-host disease (cGvHD)—a condition where transplanted immune cells attack your body—that did not improve with steroid treatment alone. The trial aims to help patients whose disease is resistant to standard steroids.
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