Adagrasib with brain radiation for KRAS G12C lung cancer with brain mets
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This study tests a targeted pill (adagrasib) combined with focused radiation to the brain (SRS) for people with KRAS G12C-mutated lung cancer that has spread to the brain. The goal is to see if this combination can control brain tumors while treating the rest of the body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have stage IV non-small cell lung cancer that has spread and a KRAS G12C mutation in your tumor or blood.
- You have at least one untreated brain metastasis (2mm to 3cm in size) that can be treated with focused radiation (SRS).
- You have not had a prior KRAS G12C inhibitor drug like sotorasib or adagrasib.
- You have had no more than 2 prior lines of treatment for advanced lung cancer, or you have had no treatment yet.
- You are in generally good health (able to care for yourself) and have adequate kidney, liver, and blood counts.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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