MASCT-I plus chemo for first-line advanced soft tissue sarcoma
Treatments studied
Part of Brain & nervous system, Cancer, Women’s health & pregnancy clinical trials.
This trial tests a new immune cell therapy (MASCT-I) combined with standard chemotherapy (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who have not had prior chemotherapy or targeted therapy. The goal is to see if the combination works better than chemo alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have a type of soft tissue sarcoma that cannot be removed by surgery or has spread to other parts of your body.
- You have not received chemotherapy or targeted therapy for advanced sarcoma, or if you had neoadjuvant or adjuvant therapy, your cancer came back more than 6 months after that ended.
- You have at least one tumor that can be measured on scans.
- You are in good enough health to carry out daily activities (ECOG score 0 or 1), and your doctor expects you to live at least 6 more months.
- You have adequate organ function (blood counts, kidney, liver, lung) and are willing to use birth control during and for 6 months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of immunotherapy (a treatment that helps your immune system attack cancer) and artificial intelligence (AI) technology as the first treatment for certain types of advanced soft tissue sarcoma. It aims to see if this approach can shrink tumors or stop them from growing better than current options.
This trial tests a combination of two drugs—gemcitabine (a chemotherapy drug) and nab-sirolimus (a targeted therapy)—for people with advanced soft-tissue sarcoma or leiomyosarcoma, especially those whose tumors have a specific genetic change in the TSC2 or TSC1 genes. The goal is to see if this combination can shrink tumors or slow their growth.
This Phase 2 trial tests a combination of chemotherapy drugs (Adriamycin and ifosfamide) together with an immunotherapy drug (sintilimab) for advanced soft-tissue sarcoma that can’t be removed by surgery or has stopped responding to standard treatment. It aims to shrink tumors and help control the cancer by boosting the immune system along with chemotherapy.
This trial combines cryoablation (a freezing technique to destroy tumors) with camrelizumab (an immunotherapy drug that helps your immune system fight cancer) for patients with advanced soft tissue sarcoma that hasn't responded to standard treatments. The goal is to see if this combination works better than current options.
This trial tests a new immunotherapy drug (envafolimab) combined with two chemotherapy drugs (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who have not had prior treatment. The goal is to see if this combination is safe and effective.
This study tests whether giving radiation, chemotherapy, and immunotherapy together can control high-risk soft tissue sarcoma that is hard to remove or may come back after surgery. It may help by attacking cancer in different ways, including boosting the immune system.
Hear when a new Leiomyosarcoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.