Spleen shrinking procedure for severe hypersplenism
Part of Blood & lymphatic, Digestive system clinical trials.
This trial tests a procedure that uses heat or cold to shrink part of the spleen and block some of its blood supply, which may improve low blood counts caused by cirrhosis-related hypersplenism. It is for patients whose low white blood cells or platelets have not improved with medicine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have severe hypersplenism (enlarged spleen destroying blood cells) caused by cirrhosis (scarring of the liver).
- Your white blood cells are less than 3000, and/or your platelets are less than 50000.
- Standard medicines to raise blood cell counts haven't worked well for you.
- You are having symptoms (like anxiety) or other problems from hypersplenism that need treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is testing a keyhole surgery to remove part of an enlarged spleen in people with cirrhosis. It aims to improve low blood counts and reduce the risk of further bleeding from stomach or esophagus veins.
This study tests a new procedure that uses an ultrasound-guided scope to shrink part of the spleen (called partial splenic embolization). This may help improve your low platelet count and reduce the risk of future bleeding, especially when other treatments have not been tried.
This study looks at whether removing the spleen using keyhole surgery can improve “liver reserve function” in people with cirrhosis. It may be considered for patients who have an enlarged spleen and very low platelets, but it also has several safety exclusions.
This trial looks at whether a minimally invasive spleen surgery (with a specific vein-disconnection procedure) can better protect liver function in people with cirrhosis who have had variceal bleeding. It may help reduce stress on the liver after treatment, but you must meet several safety criteria.
This study looks at whether removing an enlarged spleen (splenectomy) in people with cirrhosis can improve their blood fat (lipid) levels over two years. It may help those with low blood counts due to an overactive spleen.
This study tests whether removing an enlarged spleen through keyhole surgery can improve kidney function in people with cirrhosis and an overactive spleen. The trial follows patients for two years to see if the surgery helps protect the kidneys.
Hear when a new Secondary Hypersplenism trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.