Ear, nose, and throat inflammation study in eGPA
Part of Blood & lymphatic, Heart & circulation, Immune system & allergy, Skin clinical trials.
This study looks at inflammation in the ear, nose, and throat area in people with different conditions, including nasal polyps, severe asthma, eGPA (a rare blood vessel disease), and GPA (another rare disease). It compares them to healthy volunteers to better understand what causes local inflammation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have one of these conditions: nasal polyps, severe asthma, eosinophilic granulomatosis with polyangiitis (eGPA), or granulomatosis with polyangiitis (GPA), OR you are a healthy volunteer.
- If you have nasal polyps, you must not have asthma or eGPA.
- If you are a healthy volunteer, you must not have asthma or a history of airway overreactivity.
- You have not smoked in the last 6 months and are not using Dupilumab (an asthma/eczema medication) or other immune-suppressing drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests how well mepolizumab works for people with asthma or a related condition called EGPA, and looks for markers in the blood that may predict organ damage or treatment response.
This registry study looks at adults with high eosinophils (a type of immune cell) that are believed to be causing damage in the airways or lungs. It aims to better identify these eosinophils and understand what is going on so future treatments can improve.
This study looks at how the immune system and the esophageal barrier function in people with eosinophilic esophagitis (EoE) compared to those without. It involves taking biopsies during an upper endoscopy to understand the disease better. The results may help improve treatments for EoE.
This study looks at different “immune inflammation patterns” in people with asthma and/or nasal polyps. It may help researchers better tailor future treatments by figuring out which patterns go with which symptoms.
This trial tests a new medicine called SHR-1703 for people with EGPA that has come back or is hard to treat. It aims to see if the drug can help control the disease better.
This study follows people with asthma (with or without nasal polyps) to learn more about how the disease changes over time. If you already take part in the MEGA cohort or use a biologic drug for severe asthma, this may be a way to contribute to research while continuing your normal care.
Hear when a new EGPA - Eosinophilic Granulomatosis With Polyangiitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.