Lowering treatment for Stage II testicular cancer
Part of Cancer clinical trials.
This trial tests lowering the intensity of treatment (de-escalation) for Stage II seminoma, a type of testicular cancer. You may receive either a surgery to remove lymph nodes or a single round of chemotherapy (carboplatin), instead of more aggressive standard treatments, to see if it's safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of testicular cancer called seminoma.
- Your cancer is Stage II (it has spread to nearby lymph nodes).
- You have not had chemotherapy or radiation for this cancer before.
- You are willing to complete questionnaires about your health and well-being.
- For the surgery option: lymph nodes are small (under 3 cm) and you are healthy enough for surgery (BMI under 34, no serious heart/lung problems).
- For the carboplatin option: kidney function is adequate and you agree to use contraception if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether you can have less intense treatment (“de-escalation”) while still treating a small, limited-stage testicular seminoma that is growing. It may help reduce side effects if you qualify.
This trial is testing whether removing affected lymph nodes with surgery (RPLND) works well alone for seminoma testicular cancer that has spread to nearby nodes but is still relatively small. It is for patients who have not had extensive chemo or radiation.
This study compares two standard treatments—surgery to remove lymph nodes in the abdomen (RPLND) versus chemotherapy—for men with testicular cancer that has spread to a small area in the abdomen. The goal is to see which approach works better and has fewer side effects.
This Phase 2 study tests a treatment plan guided by a PET scan over time in people with seminoma after testicle removal. It aims to tailor therapy based on how cancer shows up on the scan, potentially helping avoid unnecessary treatment intensity.
This trial tests whether proton beam radiation (a precise form of cancer treatment) can effectively treat early-stage testicular cancer that has spread to nearby lymph nodes while reducing side effects. You would receive this specialized radiation after surgery to remove the testicle.
This study compares giving radiation versus observation (no immediate radiation) for men with advanced seminoma whose PET-CT scan shows a leftover mass after first-line chemotherapy. It aims to see which approach controls the disease better while protecting quality of life.
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