Surgery vs. chemo for testicular cancer that has spread
Part of Cancer, Hormones & metabolism, Kidney & urinary clinical trials.
This study compares two standard treatments—surgery to remove lymph nodes in the abdomen (RPLND) versus chemotherapy—for men with testicular cancer that has spread to a small area in the abdomen. The goal is to see which approach works better and has fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18 or older
- Testicular cancer that has spread to up to 2 lymph nodes in the abdomen, each smaller than 30 mm
- Either newly diagnosed seminoma (stage II A/B) or a relapse of seminoma in the abdomen
- Or newly diagnosed good-prognosis germ cell tumor (seminoma or nonseminoma) that requires 3-4 rounds of chemotherapy
- No prior chemotherapy or surgery (RPLND) for this cancer
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if removing the involved lymph nodes in the abdomen (retroperitoneal lymph node dissection) is a good treatment for seminoma that has spread to a small number of lymph nodes. It may help patients avoid more chemotherapy or radiation.
This trial tests lowering the intensity of treatment (de-escalation) for Stage II seminoma, a type of testicular cancer. You may receive either a surgery to remove lymph nodes or a single round of chemotherapy (carboplatin), instead of more aggressive standard treatments, to see if it's safe and effective.
This trial is testing whether removing affected lymph nodes with surgery (RPLND) works well alone for seminoma testicular cancer that has spread to nearby nodes but is still relatively small. It is for patients who have not had extensive chemo or radiation.
This study reviews 20 years of experience in removing lymph nodes in the abdomen (RPLND) for testicular cancer. It aims to understand the outcomes of this surgery for people who had it after chemotherapy or for early-stage cancer.
This study looks at how people should be followed after treatment for testicular cancer (surgery and, for some, chemotherapy). It may help improve follow-up plans while keeping an eye out for cancer coming back.
This study tests whether you can have less intense treatment (“de-escalation”) while still treating a small, limited-stage testicular seminoma that is growing. It may help reduce side effects if you qualify.
Hear when a new Testicular Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.