Clin2
NCT05529251Possibly a fitRecruiting

Lower-dose treatment for small stage II seminoma

SeminomaStage II

Part of Cancer clinical trials.

This trial tests whether a less intensive treatment can be used for testicular seminoma that has spread to nearby lymph nodes but is still small (under 3 cm). It aims to keep the cure rate high while reducing side effects.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
90 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older.
  • You have had surgery to remove a testicular seminoma, and it has spread to lymph nodes in the abdomen or pelvis (stage IIa/IIb) with the largest lymph node under 3 cm.
  • The cancer is growing (confirmed by a PET scan or two CT scans showing bigger lymph nodes).
  • You have not had chemotherapy or radiation therapy before.
  • Your blood tests show good liver, kidney, and bone marrow function, and your AFP (a protein that may indicate cancer) is normal.
  • You are willing to use contraception or abstain from sex during the study and for 12 months after treatment, and to consider sperm banking before treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06309745Recruiting
Lowering treatment for Stage II testicular cancer

This trial tests lowering the intensity of treatment (de-escalation) for Stage II seminoma, a type of testicular cancer. You may receive either a surgery to remove lymph nodes or a single round of chemotherapy (carboplatin), instead of more aggressive standard treatments, to see if it's safe and effective.

London
NCT07601672Not yet recruiting
Proton beam therapy for stage ii testicular seminoma

This study tests if proton beam therapy, a precise type of radiation, is safe and effective for men with early-stage testicular seminoma that has spread to abdominal lymph nodes. It aims to reduce side effects compared to standard radiation while keeping the cancer controlled.

NCT06144736Recruiting· Phase 2
Surgery for stage 2 seminoma testicular cancer trial

This trial is testing whether removing affected lymph nodes with surgery (RPLND) works well alone for seminoma testicular cancer that has spread to nearby nodes but is still relatively small. It is for patients who have not had extensive chemo or radiation.

Düsseldorf
NCT05142982Recruiting
Radiation or watchful waiting after chemo for seminoma

This study compares giving radiation versus observation (no immediate radiation) for men with advanced seminoma whose PET-CT scan shows a leftover mass after first-line chemotherapy. It aims to see which approach controls the disease better while protecting quality of life.

Mumbai, Maharashtra
NCT07498959Recruiting
Surgery vs. chemo for testicular cancer that has spread

This study compares two standard treatments—surgery to remove lymph nodes in the abdomen (RPLND) versus chemotherapy—for men with testicular cancer that has spread to a small area in the abdomen. The goal is to see which approach works better and has fewer side effects.

Gothenburg, Göteborg
NCT05705687Recruiting
Testing a treatment plan for higher-risk testicular cancer

This trial checks whether a specific treatment approach works better for men with higher-risk non-seminomatous germ-cell tumors that have spread. Doctors will use tumor marker changes and where the cancer started (often the chest area) to help guide treatment choices.

Villejuif

Hear when a new Seminoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.