Clin2
NCT06311214Possibly a fitRecruiting

Personalized ADC therapy for advanced solid tumors

Advanced Malignant Solid NeoplasmMetastatic Malignant Solid Neoplasm

Treatments studied

Part of Cancer clinical trials.

This trial tests personalized antibody-drug conjugates (ADCs) for advanced solid tumors. It looks for specific proteins on your tumor cells to match you with a treatment that targets them directly.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
500 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must have an advanced or metastatic solid tumor that is not curable with standard treatments.
  • You need to have a tumor tissue sample tested for certain proteins (like Trop-2, Nectin-4, or HER2) to see if you qualify.
  • You must be willing to have a biopsy of your tumor before and during the study.
  • You should have had no more than 3 prior chemotherapy treatments for advanced cancer.
  • You need to be in fairly good health (able to do daily activities) with adequate organ function.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05564377Recruiting· Phase 2
Find targeted cancer treatments using genetic testing

This study matches people with advanced solid tumors to targeted treatment plans based on genetic testing. It also requires tumor sample testing to help doctors choose the most promising therapy for your specific tumor changes.

Birmingham, Alabama
NCT07259226Recruiting· Phase 2
Studying resistance to antibody-drug conjugates in advanced cancer

This study is for people with advanced breast, bladder, lung, or stomach cancer who are about to start treatment with a type of targeted therapy called an antibody-drug conjugate (ADC). The trial will collect tumor samples and blood to understand how cancers become resistant to these drugs and to find better ways to predict treatment success.

Villejuif
NCT07162259Not yet recruiting· Phase 4
Study of a targeted antibody-drug therapy for advanced breast cancer

This study tests a new type of targeted therapy called an antibody-drug conjugate (ADC) for advanced breast cancer that is hormone-receptor-positive and HER2-negative. It is for people whose cancer has progressed after CDK4/6 inhibitor treatment, and may offer a new option to slow tumor growth.

Xi'an
NCT07825753Not yet recruiting· Phase 2
Personalized targeted therapy for advanced pancreatic and breast cancer

This trial tests a new medicine that targets cancer cells with specific proteins, to see if it can stop the growth of advanced pancreatic and breast cancer when other treatments have stopped working. It is an umbrella study, which means different protein-matched drugs are tested for different cancer types.

Shanghai, Shanghai Municipality
NCT02693535Recruiting· Phase 2
Targeted drug testing for advanced cancer with tumor gene changes

This trial tests whether FDA-approved targeted drugs can help people with advanced cancer whose tumors have specific gene changes. It aims to match your tumor's unique genetic profile to a drug that may work better for you.

Birmingham, Alabama
NCT06649331Recruiting· Phase 2
Re-trying antibody-drug conjugates for advanced breast cancer

This study looks at whether giving a different antibody-drug conjugate (ADC) after a previous one can help people with advanced or metastatic breast cancer. It aims to find new options for patients who have already had ADC treatment.

Shanghai, Shanghai Municipality

Hear when a new Metastatic Malignant Solid Neoplasm trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.