Combination therapy study for advanced solid tumors
Treatments studied
Part of Cancer, Digestive system, Hormones & metabolism, Lungs & breathing, Skin, Women’s health & pregnancy clinical trials.
This trial is testing two new drugs (DB-1311 with BNT327 or DB-1305) in people with certain advanced or metastatic solid tumors that have not responded to prior treatments. It aims to see if the combination shrinks tumors or slows cancer growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have cancer that can be measured on scans (at least one measurable tumor)
- Your doctor expects you to live at least 3 more months
- You are able to get around and care for yourself (ECOG performance status 0 or 1)
- Your organ function (kidneys, liver, etc.) is adequate based on blood tests
- You have not been treated with a B7H3-targeted drug or an antibody-drug conjugate containing a topoisomerase inhibitor
- You do not have uncontrolled infections, heart problems, fluid buildup in the chest/belly, lung inflammation, or autoimmune disorders
- You do not have cancer spread to the brain or spinal cord that is causing symptoms
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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