Parecoxib vs morphine for sickle cell pain in the ER
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial tests if a non-steroidal anti-inflammatory drug (parecoxib) works as well as morphine for treating sickle cell pain crises in the emergency room. The goal is to find a safer pain relief option for people with sickle cell disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be over 18 years old with sickle cell disease
- You are having a moderate to severe pain crisis (vaso-occlusive crisis)
- Your pain is not from other causes like acute chest syndrome or infection
- You weigh more than 50 kg (about 110 pounds)
- You have not taken opioids or NSAIDs in the past 24 hours
- You do not have any condition that makes NSAIDs unsafe (like allergy, asthma, kidney disease, or pregnancy)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding lidocaine to standard pain treatment can reduce the amount of morphine or oxycodone needed for a severe pain crisis or acute chest syndrome in sickle cell disease. It is for adults in the ICU who have already started opioid treatment within the last 72 hours.
This trial tests a fentanyl-like nose spray (sufentanil) to relieve severe pain from a sickle cell crisis in children and teens. It aims to see if it works better than usual pain treatments.
This trial studies an approach to improve care during emergency room visits for uncomplicated sickle cell pain crises. It may help by guiding how pain is treated in the ER and tracking outcomes for people with sickle cell disease.
This trial tests if a low dose of ketamine can help relieve pain for people with sickle cell disease who come to the emergency room with a pain crisis. It aims to find a better way to manage pain during these episodes.
This trial tests a pain medicine called ketorolac (an NSAID) to see if it helps children with sickle cell disease who come to the emergency room or clinic with sudden, severe pain. If your child has sickle cell disease and is having an acute pain crisis, this study may be an option.
This trial tests whether taking ketamine by mouth can help treat “vaso-occlusive” pain episodes that may require hospital admission. If it works, it could offer an easier way to manage severe pain during sickle cell crises.
Hear when a new Sickle-Cell Disease with Crisis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.