Clin2
NCT06340789Possibly a fitRecruiting

Sodium Benzoate Added to Antipsychotics for Resistant Schizophrenia

Symptom, CognitiveSchizophreniaSchizo Affective Disorder

Part of Brain & nervous system, Mental health clinical trials.

This study tests whether adding a supplement called sodium benzoate to your current antipsychotic medication can improve symptoms in schizophrenia that hasn't responded well to standard treatments. Researchers will measure brain chemistry changes and symptom improvement over time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
90 people
Ages
20 years to 55 years
Study type
Interventional

Who can take part

  • Diagnosed with schizophrenia or schizoaffective disorder (a related condition with mood changes)
  • Your symptoms have not improved despite trying at least 2 different antipsychotic medications at adequate doses for at least 6 weeks each
  • You have had persistent symptoms for at least 6 months without getting significantly better
  • You do not have other medical conditions, neurological disease, or substance use disorder
  • You can safely have an MRI scan (brain imaging) and do not have metal implants that prevent it
  • You are willing to have blood samples taken to measure brain chemistry

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04959201Recruiting· Phase 2
NMDA and antioxidant add-on to treat schizophrenia symptoms

This Phase 2 trial tests whether adding an “NMDA-enhancing” treatment plus an antioxidant can improve ongoing schizophrenia symptoms over 12 weeks. It’s meant for people who still have symptoms even though their usual antipsychotic dose has been stable for at least 3 months.

Taichung
NCT05240976Recruiting· Phase 2
Testing add-on treatments for very treatment-resistant schizophrenia

This trial tests a combination of an NMDA-targeting medicine and an anti-inflammatory treatment for people with schizophrenia that has not responded well to several standard treatments, including clozapine. If you qualify, the goal is to see whether this combination improves symptoms more than usual care.

Taichung
NCT06021197Recruiting· Phase 2
NMDA-enhancing treatment for cognitive symptoms in schizophrenia

This study tests a new treatment that may help with thinking and memory problems in people with schizophrenia. It is for people whose schizophrenia symptoms are stable and who are already on a steady medication.

Taichung
NCT06574360Recruiting· Phase 2
Study of a dual-target drug for hard-to-treat schizophrenia

This trial tests an experimental combination treatment that targets two different brain receptors (sigma-1 and NMDA) to see if it can improve symptoms in people with schizophrenia that hasn't responded well to standard antipsychotics.

Taichung
NCT04917302Recruiting· Phase 2
NMDA and anti-inflammatory add-on for treatment-resistant schizophrenia

This trial tests whether combining an NMDA “signal-supporting” treatment with an anti-inflammatory medicine can reduce symptoms in people with schizophrenia who don’t respond well to usual antipsychotic drugs. If you’ve tried at least two antipsychotics and you’re still symptomatic, this study may be worth screening for.

Taichung
NCT07122895Recruiting· Phase 2
NMDA enhancer for negative symptoms in schizophrenia

This study tests whether a medication that boosts brain NMDA receptors can improve negative symptoms in schizophrenia, and looks at differences between men and women. It is for people with stable schizophrenia who still have mostly flat mood or low motivation.

Taichung

Hear when a new Schizophrenia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.