Radiation, immunotherapy, and targeted therapy before surgery for liver cancer with portal vein tumor thrombus
Part of Cancer, Digestive system clinical trials.
This trial tests whether combining radiation (IMRT) with two drugs—camrelizumab (an immunotherapy) and apatinib (a targeted therapy)—before surgery can help people with liver cancer that has spread to the main blood vessel of the liver (portal vein). The goal is to shrink the tumor and improve surgical outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have liver cancer that can be removed with surgery, and it has spread to the main blood vessel in your liver (portal vein tumor thrombus).
- You are between 18 and 75 years old.
- Your liver function is good (Child-Pugh class A) and you are able to perform daily activities without much help (ECOG score 0 or 1).
- You have not had any prior cancer treatment like surgery, chemotherapy, radiation, or targeted therapy.
- You are willing to provide a fresh tumor sample and blood samples for research.
- You have adequate blood cell counts and organ function as determined by lab tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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