Testing angiotensin II for refractory distributive shock
Treatments studied
Part of Heart & circulation clinical trials.
This study tests an injection of angiotensin II (a substance that helps tighten blood vessels) versus a placebo for patients with distributive shock that is not responding to standard treatments. It may help raise blood pressure and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 75 years old.
- You are diagnosed with distributive shock (a type of shock where blood vessels widen too much).
- Despite high doses of blood pressure support medications for at least 6 hours, your average blood pressure stays between 55 and 70 mmHg or is not reaching the target.
- You have received at least 30 mL/kg of fluids in the last 24 hours or have had enough fluids as judged by your doctor.
- You have a high cardiac output (heart pumping well) or high oxygen levels in your central veins, along with a high central venous pressure.
- You have a central line and an arterial line in place, and are expected to keep them for at least 48 hours.
- You do not have certain conditions like severe burns, liver failure, active bleeding, or recent cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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