Early blood pressure medication in the ER
Treatments studied
Part of Infections clinical trials.
This trial tests a drug called angiotensin II for people in the emergency room who need a specific dose of norepinephrine (a medicine to raise blood pressure) and are also getting antibiotics. The goal is to see if giving angiotensin II early can help stabilize blood pressure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old
- You must be receiving a moderate dose of norepinephrine (a blood pressure medicine) through an IV, even after getting enough fluids
- You must be getting IV antibiotics or your doctor plans to give them
- You (or your legal representative) must be able to sign a consent form
- You cannot have a current heart attack (acute coronary syndrome) or certain other heart conditions
- You cannot have bleeding that requires blood transfusions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two medicines—norepinephrine and angiotensin II—to see which one works better at raising blood pressure in people with septic shock (a severe infection that causes dangerously low blood pressure). It aims to find out which approach helps patients recover better.
This trial tests whether different blood pressure medicines protect kidney function better in people with septic shock (a severe infection that causes low blood pressure). It compares norepinephrine (the standard treatment) with other options to see which is best for the kidneys.
This trial tests whether giving a medicine called norepinephrine early and adjusting the dose quickly can help people with sepsis who have very low blood pressure. It is for adults who are diagnosed within the last 3 hours and who have not already received this medicine.
This trial tests whether giving a second medicine called vasopressin early (along with norepinephrine) helps people with sepsis and low blood pressure better than waiting to use vasopressin only if norepinephrine doesn't work. It may improve blood pressure control and reduce the need for strong medicines.
This trial tests whether adding vasopressin (a hormone that narrows blood vessels) to usual care can improve recovery in patients with septic shock (a severe infection causing very low blood pressure). If you are already on a strong blood pressure medication, this study may help stabilize your condition.
This trial tests a medicine called angiotensin II to see how well it helps people whose blood pressure stays dangerously low after standard treatments for vasoplegic shock, a condition where blood vessels relax too much. If it works, it might help raise blood pressure and improve blood flow to vital organs.
Hear when a new Septic Shock trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.