Combination therapy for advanced CML
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new combination of three drugs (a third-generation TKI, azacitidine, and a Bcl-2 inhibitor) for people with chronic myeloid leukemia that has progressed to a more advanced phase (myeloid blast phase). The goal is to see if this combination is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your CML is Philadelphia chromosome-positive (Ph+) or BCR::ABL-positive.
- Your kidney function is adequate (creatinine clearance at least 50 mL/min).
- Your liver function is adequate (bilirubin and liver enzymes within certain limits).
- Your heart function is adequate (ejection fraction > 50% and normal heart rhythm).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of three drugs (olverembatinib, venetoclax, and azacitidine) for people with a fast-growing form of chronic myeloid leukemia (CML) called blast phase. The goal is to see if this treatment can help control the leukemia when it has moved to a more aggressive stage.
This trial is testing a three-drug combination for people newly diagnosed with a type of AML that has a FLT3 mutation. The goal is to see if this treatment works better than standard care.
This trial tests a combination of three chemotherapy drugs (venetoclax, azacitidine, and cytarabine) for people newly diagnosed with acute myeloid leukemia who have never received AML treatment before. The goal is to see if this combination can help patients go into remission and live longer.
This trial tests a combination of targeted drugs (ABL/JAK inhibitors) with chemotherapy and venetoclax for people with a type of leukemia called Ph-like ALL. It aims to see if this treatment is safe and effective.
This trial tests a combination of three drugs (venetoclax, azacitidine, and liposomal mitoxantrone) as a first treatment for people newly diagnosed with acute myeloid leukemia (AML). The goal is to see if this combination works better than standard care.
This trial tests a combination of three drugs (pacritinib, venetoclax, and azacitidine) in people whose myeloproliferative neoplasm (MPN) has progressed to a faster-growing, more aggressive phase (accelerated or blast phase). The goal is to see if this combination is safe and effective.
Hear when a new Chronic Myeloid Leukemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.