First human trial of CDR404 for MAGE-A4 positive solid tumors
Part of Cancer clinical trials.
This trial tests an experimental treatment called CDR404 for people with certain advanced solid tumors. It is designed for those whose tumors have a specific protein (MAGE-A4) and who have already tried other treatments. The goal is to see if the treatment is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a specific immune system type (HLA-A*02:01), tested by a blood test.
- Your tumor has a protein called MAGE-A4 on its surface.
- You are able to do most daily activities without help (ECOG score 0 or 1).
- You have already tried standard treatments and they didn't work or caused bad side effects.
- You have a tumor that can be measured on a scan (like a CT or MRI).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new type of immune therapy called MAGE-A4-directed TCR-T. It uses your own immune cells (T cells) that are modified to find and attack cancer cells that have a specific protein (MAGE-A4). It is for people with advanced solid tumors who have already tried other treatments.
This trial tests a personalized cell therapy called TCR-T that targets a protein called MAGE-A4 on tumor cells. It is for people with advanced sarcomas or similar cancers that have not responded to standard treatments.
This trial tests a new drug called MDX2004 for people with advanced solid tumors (cancer that has spread or can't be removed). The goal is to see if the drug is safe and if it helps shrink tumors.
This trial tests a new drug, MRG006A, for people with advanced solid tumors, especially liver cancer. It aims to see if the drug is safe and effective by targeting a protein called GPC3 found on some cancer cells.
This trial tests a new drug called ADRX-0405 in people with advanced solid tumors like prostate, stomach, or lung cancer. The goal is to see how safe it is and if it shrinks tumors.
This trial tests a new drug called AROG4-01 for people with advanced solid tumors that have stopped responding to standard treatments. It aims to find the right dose and see if the drug can help shrink or slow tumor growth.
Hear when a new Select Advanced Solid Tumors trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.