Blood thinner or none for atrial fibrillation with dialysis
Treatments studied
Part of Heart & circulation, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial compares two types of blood thinners (vitamin K antagonists and factor Xa inhibitors) versus no blood thinner in people with atrial fibrillation who are on dialysis or have very advanced kidney disease. It aims to see which option is safest and most effective for preventing strokes and bleeds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have atrial fibrillation (a fast, irregular heartbeat).
- Your kidney function is very low (eGFR 15 or less) or you are on chronic dialysis.
- Your stroke risk score (CHA2DS2-Vasc) is at least 2 (or 3 if you are female).
- You have not had a major bleed or stroke in the last month.
- You do not have a mechanical heart valve or severe mitral stenosis.
- You are not already on a blood thinner for another reason (like a blood clot) and you are not on dual antiplatelet therapy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests apixaban (a blood thinner) to prevent stroke in people with atrial fibrillation or atrial flutter who have very poor kidney function or are on dialysis. If you qualify, you may help researchers find a safer way to lower stroke risk for this higher-risk group.
This study compares two strategies for managing atrial fibrillation (irregular heartbeat) in people on dialysis: one uses a blood thinner called apixaban to prevent strokes, and the other does not. The goal is to find out which approach is safer and more effective for this specific group.
This trial studies whether the blood thinner warfarin is safe and effective for preventing stroke and blood clots in people who have atrial fibrillation and need long-term dialysis. It may help your care team better balance clot prevention against bleeding risk.
This study compares two blood-thinning medicines to see which works better for people who have both atrial fibrillation (irregular heartbeat) and heart disease. It aims to reduce the risk of heart attack or stroke while avoiding bleeding problems.
This study tests if apixaban (a newer blood thinner) is safer and works as well as warfarin (a standard blood thinner) for patients on peritoneal dialysis who have atrial fibrillation (an irregular heartbeat). It aims to reduce the risk of stroke and bleeding.
This study tests a new blood thinner to prevent strokes and blood clots in people with atrial fibrillation (a common heart rhythm problem). You may qualify if you have atrial fibrillation and at least one risk factor for stroke, or if you've never taken a blood thinner before.
Hear when a new Atrium; Fibrillation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.