Blood thinner or none for atrial fibrillation with dialysis
Treatments studied
Part of Heart & circulation, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial compares two types of blood thinners (vitamin K antagonists and factor Xa inhibitors) versus no blood thinner in people with atrial fibrillation who are on dialysis or have very advanced kidney disease. It aims to see which option is safest and most effective for preventing strokes and bleeds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have atrial fibrillation (a fast, irregular heartbeat).
- Your kidney function is very low (eGFR 15 or less) or you are on chronic dialysis.
- Your stroke risk score (CHA2DS2-Vasc) is at least 2 (or 3 if you are female).
- You have not had a major bleed or stroke in the last month.
- You do not have a mechanical heart valve or severe mitral stenosis.
- You are not already on a blood thinner for another reason (like a blood clot) and you are not on dual antiplatelet therapy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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