Natural history study of lung papillomatosis

This early-phase trial tests how well pembrolizumab plus lenvatinib can treat respiratory papillomas that have spread to the lungs. It may help people whose lung disease is caused by human papillomavirus (HPV).

This Phase 1 trial is testing a vaccine made from your own immune cells (dendritic cells) that may help your body fight the virus causing recurrent papillomas in your voice box. It is for people whose papillomas are caused by HPV type 6, who have had at least one recurrence in the past year.

This trial tests if people with recurrent respiratory papillomatosis (growths in the airway caused by HPV) can safely get more doses of the study drug Zopa and checks if the virus spreads after treatment. It may help people who have already tried Zopa or are considering it for the first time.

This trial tests whether a booster shot of the Gardasil-9 vaccine can help adults with recurrent respiratory papillomatosis (RRP) go longer between treatments. If you've already had the full vaccine series more than two years ago and still have RRP flare-ups, this booster might reduce how often you need surgery.

This study is creating a national group of patients with juvenile recurrent respiratory papillomatosis, a condition causing wart-like growths in the airway. It aims to learn more about the disease and improve care.

This trial combines two drugs, bevacizumab (Avastin) and PRGN-2012, to see if they control throat and airway growths linked to recurrent respiratory papillomatosis. You must have already tried PRGN-2012 before.