Clin2
NCT06417008Likely a fitRecruiting

Combination targeted therapy for advanced EGFR-mutant lung cancer

Non-Squamous Non-Small Cell Lung Cancer

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial tests a new combination of two targeted drugs (HS-20117 and aumolertinib) in people with advanced EGFR-mutant lung cancer who haven't had treatment yet. The goal is to see if the combination works better than current standard treatments.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
1,080 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • You have advanced non-small cell lung cancer (stage IIIB, IIIC, or IV) that has not been treated yet.
  • Your tumor has a type of EGFR mutation (a genetic change that makes it respond to certain targeted drugs).
  • You are willing and able to provide a sample of your tumor tissue (either new or from a past biopsy).
  • You have at least one tumor that can be measured on scans (like a CT or MRI).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06752408Not yet recruiting· Phase 2
Comparing two EGFR-targeted pills for advanced lung cancer

This trial compares two targeted therapy pills, aumolertinib and osimertinib, for people with a specific EGFR mutation in advanced non-small-cell lung cancer that has spread. Both drugs are designed to block cancer growth signals. The study aims to see which one works better as a first treatment.

Beijing, Beijing Municipality
NCT07873086Not yet recruiting
Aumolertinib after surgery for EGFR-mutant lung cancer

This trial tests whether taking aumolertinib (a pill that targets specific EGFR mutations) after lung cancer surgery helps prevent the cancer from coming back. It is for people with early-stage non-small cell lung cancer that has an EGFR mutation and has been completely removed.

Beijing, Beijing Municipality
NCT05778149Not yet recruiting· Phase 2
Combination targeted therapy for advanced lung cancer with egfr and tp53 mutations

This study tests a combination of two oral targeted drugs—aumolertinib (which targets EGFR) and anlotinib (which blocks blood vessel growth to the tumor)—as a first treatment for advanced lung cancer that has both EGFR and TP53 mutations. It aims to see if the combination works better and is safe compared to standard care.

NCT06102928Recruiting
Anlotinib plus Aumolertinib for first-line treatment of advanced EGFR-mutant lung cancer

This trial tests a combination of two targeted drugs (anlotinib and aumolertinib) as the first treatment for advanced lung cancer with a specific EGFR mutation (L858R). The goal is to see if the combination works better than standard care.

Kunming, Yunnan
NCT07645222Recruiting· Phase 1
Testing HS-20122 combined therapy for advanced lung cancer

This early-stage trial tests a new drug combination (HS-20122) for non-small cell lung cancer that has spread or cannot be surgically removed. You may qualify if your cancer has progressed despite prior treatment or you haven't received prior treatment yet.

Guangzhou, Guangdong
NCT07130916Recruiting· Phase 1
Aumolertinib study for European patients with lung cancer

This study tests a new targeted therapy, Aumolertinib, for adults with a specific type of advanced lung cancer (non-small cell lung cancer) that has certain genetic changes (EGFR mutations). The goal is to see if the drug can shrink or slow the cancer.

Banja Luka

Hear when a new Non-squamous Non-small Cell Lung Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.