Immunotherapy plus chemo for aggressive sarcoma
Treatments studied
Part of Cancer clinical trials.
This trial compares a combination of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) versus chemotherapy alone for people with aggressive, poorly differentiated sarcomas that have spread or cannot be removed. The goal is to see if adding immunotherapy helps shrink tumors or slow their growth better than chemotherapy alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a specific type of sarcoma (like dedifferentiated liposarcoma or undifferentiated pleomorphic sarcoma) that has spread or cannot be surgically removed.
- You have not had chemotherapy with doxorubicin (or similar drugs) before.
- You have not had immunotherapy (like PD-1/PD-L1 inhibitors) before.
- Your heart, kidney, and liver function are within certain limits, and you are able to perform daily activities without major help.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This Phase 2 trial tests a combination of chemotherapy drugs (Adriamycin and ifosfamide) together with an immunotherapy drug (sintilimab) for advanced soft-tissue sarcoma that can’t be removed by surgery or has stopped responding to standard treatment. It aims to shrink tumors and help control the cancer by boosting the immune system along with chemotherapy.
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