Clin2
NCT06423898Possibly a fitRecruiting

Study on ampicillin and ceftriaxone for heart valve infection

Endocarditis, Infective

Part of Heart & circulation clinical trials.

This trial tests a combination of two antibiotics (ampicillin and ceftriaxone) to treat a heart valve infection caused by Enterococcus faecalis bacteria. It aims to see how well the medicine works and if it's safe.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
284 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You must have a heart valve infection (endocarditis) caused by Enterococcus faecalis bacteria, either confirmed or suspected.
  • You must be willing and able to sign a consent form agreeing to take part.
  • You cannot be allergic to penicillin or cephalosporin antibiotics.
  • You cannot be pregnant or breastfeeding.
  • You cannot have an infection with other bacteria besides Enterococcus faecalis.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05398679Recruiting· Phase 4
Oral antibiotics versus IV antibiotics after heart infection

This trial compares taking antibiotics by mouth versus receiving antibiotics through a vein (outpatient IV) for an infection of the heart valve. It’s designed to see whether the oral option can work as well and safely, especially after initial treatment and surgery if needed.

Alicante, Alicante
NCT07699211Not yet recruiting· Phase 3
Dalbavancin for heart valve infections

This study tests a new antibiotic called dalbavancin for treating infections of the heart valves. It may offer a simpler treatment option with fewer hospital visits.

Freiburg im Breisgau, Baden-Wurttemberg
NCT04647331Recruiting
Study antibiotic levels in heart valve infection

This trial measures how your body handles certain intravenous antibiotics used for endocarditis, an infection of the heart valves. It may help doctors understand the best antibiotic dosing for people with valve infections.

Gothenburg
NCT07345325Recruiting· Phase 3
Comparing antibiotic treatments for heart valve infections

This trial tests whether a treatment without rifampin works as well as one with rifampin for a type of heart valve infection caused by staph bacteria. It aims to find a simpler and safer option for patients with an infected artificial heart valve.

Aix-les-Bains
NCT06870409Recruiting· Phase 3
Phages plus antibiotics for heart infection treatment

This trial tests if adding bacteriophages (viruses that kill bacteria) to standard antibiotic treatment can help people with a serious heart valve infection called infective endocarditis. It may offer a new way to fight the infection.

Moscow
NCT07313865Recruiting
Blood infection study to understand heart valve infections

This study collects blood samples and medical information from patients with certain bloodstream infections to better understand why some develop a heart valve infection. The goal is to find out why some people get this complication and how to predict it.

Clermont-Ferrand, France

Hear when a new Endocarditis, Infective trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.