Oral antibiotics versus IV antibiotics after heart infection
Treatments studied
Part of Heart & circulation clinical trials.
This trial compares taking antibiotics by mouth versus receiving antibiotics through a vein (outpatient IV) for an infection of the heart valve. It’s designed to see whether the oral option can work as well and safely, especially after initial treatment and surgery if needed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and have an infection on the left side of the heart (heart valve) confirmed by accepted medical criteria
- Your specific bacteria are among the ones the study can treat with either approach (includes several common types like some streptococci, Enterococcus, Staphylococcus, and HACEK)
- You’ve already had at least 10 days of antibiotics through a vein, and at least 1 week through a vein after any heart surgery (“valve surgery”)
- Your recent symptoms and blood tests show improvement during treatment (for example, fever under 38°C for more than 2 days, and falling inflammation markers/white blood cell count)
- An ultrasound of your heart (transthoracic or transesophageal echocardiogram) was done within 48 hours of starting the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
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This trial tests if adding bacteriophages (viruses that kill bacteria) to standard antibiotic treatment can help people with a serious heart valve infection called infective endocarditis. It may offer a new way to fight the infection.
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