Psilocybin study for migraine and healthy volunteers
Treatments studied
Part of Brain & nervous system clinical trials.
This study looks at how psilocybin affects the brain in people with migraines and in healthy volunteers. The goal is to understand why it may help with headache disorders.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 70 years old.
- You have migraines (diagnosed by a doctor) or you are a healthy volunteer.
- You don't have a serious or unstable medical condition (like a brain disorder).
- You are not pregnant, breastfeeding, or planning to become pregnant, and you use reliable birth control.
- You don't have a history of psychosis or manic episodes.
- You haven't used any classic psychedelics (like psilocybin, LSD, or mescaline) in the past 6 months.
- You have not used cannabis or THC products in the past 2 weeks.
- You are not taking triptans (like sumatriptan) or ditans (like lasmiditan) more than twice a week.
- You have not taken certain serotonin-affecting preventives (like amitriptyline or fluoxetine) in the past 6 weeks.
- You have not had treatments like Botox or nerve blocks that give temporary relief.
- You don't have a bleeding disorder and you are not on blood thinners (like warfarin).
- You can avoid ibuprofen, naproxen, and similar pain relievers for 7 days before and after a PET scan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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