Testing cirtuvivint alone and with ASTX727 for leukemia and MDS
Treatments studied
Part of Blood & lymphatic, Cancer, Genetic & congenital clinical trials.
This trial tests a new drug called cirtuvivint, given alone or with another drug (ASTX727), for people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that has come back or not responded to treatment, and for people with high-risk MDS who have not been treated before. The goal is to see if these combinations work better than current options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that has come back after treatment or not responded to treatment, or you have high-risk MDS that hasn't been treated yet.
- You must be 18 years or older.
- Your kidney and liver function must be adequate, based on blood tests.
- You must not have uncontrolled infections or serious heart problems.
- Women who can get pregnant and men who can father a child must agree to use effective birth control during the study and for a period after.
- You cannot be taking certain other medications or grapefruit products that interfere with the study drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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