Engineered T cell therapy for KRAS-mutated advanced solid tumors
Part of Cancer clinical trials.
This trial tests a personalized T cell therapy designed to target specific KRAS mutations (G12V or G12D) in people with advanced solid tumors who have no standard treatment options left. The treatment involves collecting your own immune cells, engineering them to recognize and attack cancer cells with these mutations, and then infusing them back into you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have an advanced solid tumor that cannot be surgically removed and has not responded to or you cannot tolerate standard treatments.
- Your tumor has a specific KRAS mutation (G12V or G12D) and you carry the HLA-A11:01 immune type.
- You are in generally good health (ECOG performance status 0 or 1) and your organs are working well enough.
- You do not have untreated brain metastases, active infections, or a history of severe autoimmune disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new type of immune cell therapy called TCR-T that targets a specific genetic change (KRAS mutation) found in some pancreatic, colorectal, and lung cancers. If you have the right genetic markers and previous treatments haven't worked, this study may offer a new option.
This trial tests a personalized T cell therapy designed to target cancer cells with specific KRAS mutations (G12V or G12D). It may be an option for people with advanced solid tumors who have exhausted standard treatments.
This trial tests a new type of cell therapy that uses your own immune cells, specially trained to attack cancer cells with a KRAS G12V or G12D mutation. It may be an option if you have advanced solid tumors that no longer respond to standard treatments.
This Phase 1 trial tests an engineered immune cell treatment (“T cells”) made to recognize a specific tumor change (KRAS G12V) in people with advanced solid tumors. It’s intended for cancers that did not respond to standard treatments, and the goal is to see safety and early signs of benefit.
This trial tests a new therapy using your own immune cells, engineered to recognize and attack cancer cells. It is for people with advanced solid tumors who have no other standard treatment options.
This trial tests a personalized cell therapy that uses your own immune cells (T-cells) specially modified to target your tumor. It is for people with advanced solid tumors who have run out of standard treatment options.
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