Preventing neck swelling after radiation for throat cancer
Treatments studied
Part of Blood & lymphatic clinical trials.
This study tests two medicines—pravastatin (a statin) and a combination of pentoxifylline and Vitamin E—to see if they can prevent long-term swelling (lymphedema) and scarring in the neck after radiation therapy for throat cancer. Participants receive one of the medicines daily for 2 years, and regular scans help monitor any changes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have untreated throat (oropharyngeal) cancer that hasn't spread to other parts of the body.
- You are scheduled to receive radiation to your neck as part of your treatment.
- You are at least 18 years old.
- You do not have diabetes.
- You do not have serious liver disease, a history of muscle damage from statins, a recent heart attack, or an allergy to the study drugs (pravastatin or pentoxifylline/tocopherol).
- You are not pregnant or nursing, and if you could become pregnant, you agree to use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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