Combination therapy for large inoperable bile duct cancer
Part of Cancer clinical trials.
This trial looks at a combined treatment for a large, inoperable type of liver cancer (intrahepatic cholangiocarcinoma). It uses chemotherapy delivered directly into the liver, plus a targeted pill (lenvatinib) and an immunotherapy drug (PD-1 inhibitor) to try shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 70 years old.
- You must have a type of liver cancer called intrahepatic cholangiocarcinoma (bile duct cancer) that cannot be surgically removed.
- Your main tumor must be larger than 5 centimeters (about the size of a lime).
- You must be in generally good health, with adequate liver, kidney, and blood cell counts as determined by blood tests.
- You must have already started this specific treatment combination (chemotherapy into the liver, plus pills and an immunotherapy infusion) before the trial begins.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a combination of chemotherapy (gemcitabine and cisplatin) with the targeted therapy lenvatinib and the immunotherapy adebrelimab for people with advanced bile duct cancer that cannot be removed by surgery. It aims to see if this combination works better than standard treatments.
This trial tests a combination of chemotherapy directly into the liver artery, an immunotherapy drug, and a targeted therapy pill before surgery for a type of bile duct cancer that has a high chance of coming back. The goal is to see if this approach can improve outcomes for patients whose cancer is still removable but has certain high-risk features.
This study tests a combination of liver-directed therapy (D-TACE-HAIC), an immunotherapy drug (Envafolimab), and a targeted therapy pill (Lenvatinib) for people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be surgically removed. The goal is to see if this combination can shrink or control the cancer.
This Phase 3 study tests whether toripalimab (an immunotherapy) combined with lenvatinib and chemotherapy works better than standard treatment for advanced intrahepatic cholangiocarcinoma. It aims to help people live longer and/or control the cancer more effectively.
This trial tests a combination of a targeted drug (lenvatinib), an immunotherapy (PD-1 inhibitor), and chemotherapy given directly into the liver's blood supply for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer that starts in the liver). The goal is to see if this combination can shrink tumors or slow the cancer's growth.
This trial tests a combination of two drugs (surufatinib and toripalimab) plus a chemotherapy infusion directly into the liver artery (HAIC) for people with bile duct cancer that cannot be removed by surgery or has spread. The goal is to see if this combination can shrink tumors or slow the cancer.
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