Comparing nerve blocks for pain after knee replacement
Part of Bones, joints & muscles, Injuries & trauma, Pain clinical trials.
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You are scheduled for a first-time total knee replacement due to osteoarthritis.
- You will receive regional (locoregional) anesthesia, not general anesthesia.
- You are not allergic to local anesthetics (numbing medicines).
- You do not have severe kidney failure (creatinine level below 2 mg/dL).
- You have not been taking strong painkillers (opioids) or nerve pain medicines (gabapentin, pregabalin) daily for more than 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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