Testing minocycline for depression with obesity
Treatments studied
Part of Hormones & metabolism, Mental health clinical trials.
This trial tests whether adding the antibiotic minocycline to your current antidepressant helps people with both depression and obesity. It aims to see if reducing inflammation can improve mood.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have depression that hasn't improved after trying at least two different antidepressants.
- You must be currently taking an antidepressant and able to continue it during the study.
- You must be willing to undergo two MRI brain scans.
- Your blood test must show a certain level of inflammation (CRP >3 mg/L).
- You cannot have active suicidal thoughts, bipolar disorder, psychosis, OCD, or PTSD.
- You cannot have certain health conditions like autoimmune disorders, severe heart problems, or be pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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