Numbing medicine injection for knee replacement pain
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests a long-lasting numbing medicine (liposomal bupivacaine) injected around the knee during total knee replacement surgery. It aims to see if this medicine helps control pain and reduce the need for other painkillers after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- This is your first knee replacement surgery on that knee, and you have not had prior knee surgery.
- You are in good health (ASA I or II) and can understand the study instructions and pain scales.
- You are not allergic to the study drugs and have no history of opioid or alcohol abuse.
- You have not had a heart attack, stroke, blood clot, or stent placement in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
This trial tests two different numbing medicines for knee replacement surgery. It compares a long-acting numbing medicine (liposomal bupivacaine) with a standard one (ropivacaine) mixed with other drugs to see which provides better pain control. The goal is to find a way to reduce pain and improve recovery.
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
This trial tests whether a nerve block injected near the knee (with a long-acting pain medicine) works better for controlling pain after a scheduled knee replacement. It may help reduce pain and the need for stronger pain medicines after surgery.
This trial tests different doses of a long-acting painkiller (liposomal bupivacaine) injected into a nerve block in the thigh to see which dose works best for pain after knee replacement surgery. It may help you have better pain control and recover faster.
This study compares two ways of using numbing injections during total knee replacement surgery to see which better reduces pain. It may help you and your care team understand the safest and most effective pain-control approach.
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