Second TAVI for failing aortic valve replacement
Part of Heart & circulation clinical trials.
This trial is for people who have already had a TAVI (a minimally invasive aortic valve replacement) and now need a second procedure because the valve is failing. The study will test how well a redo TAVI works to fix the failing valve.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had a transcatheter aortic valve replacement (TAVI) that is now not working properly.
- The valve problem is not just leakage around the valve (paravalvular leak).
- You do not have an active heart infection (endocarditis).
- You do not have a blood clot in the valve that hasn't been treated.
- You are expected to live at least 1 more year.
- You are an adult capable of giving consent and not pregnant or nursing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies a faster, emergency version of a valve replacement done through the blood vessels (TAVI) for people with severe aortic valve narrowing. It aims to check whether this approach is safe and works when people are in urgent, hard-to-stabilize situations.
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
This study looks at how well a new valve (Myval) works when placed inside a previous TAVI valve that has stopped working properly. It may help people who need another valve replacement without open-heart surgery.
This trial tests a second transcatheter aortic valve replacement (TAVR) procedure for patients whose first TAVR valve is failing. It focuses on structural problems inside the valve, not leakage around it.
This study follows people who successfully had their first TAVI but later needed their replacement valve treated again with a “redo” TAVI. It’s mainly about tracking outcomes and safety over time to better understand who may benefit from a repeat TAVI.
This trial compares two ways to fix a previously placed TAVR heart valve that is no longer working well: surgically removing it (TAVR-explant) or placing a new TAVR valve inside it (redo-TAVR). It is for people who are having symptoms because their valve is failing.
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