Nivolumab injection for high-risk mouth lesions
Treatments studied
Part of Cancer, Mouth & dental clinical trials.
This trial tests whether injecting nivolumab directly into high-risk pre-cancerous mouth spots can prevent them from becoming cancer. You randomly receive either the drug or a placebo, and the study monitors how the spots change over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have an untreated, biopsy-confirmed pre-cancerous spot in your mouth that can be seen by looking.
- You are 18 years or older.
- You are willing to have a sample of tissue from your mouth taken or provided for testing.
- You have an ECOG performance status of 0-2 (meaning you can do daily activities with little or no help).
- Your organs (liver, kidneys, blood) are working well enough based on standard tests.
- You are not pregnant or breastfeeding, and agree to use birth control during the study and for 120 days after your last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if a special dye attached to the drug nivolumab can help surgeons see cancer cells more clearly during surgery. If you have head and neck cancer and are scheduled for surgery, this study might be an option for you.
This trial tests whether giving nivolumab (an immunotherapy drug) before surgery helps treat oral squamous cell carcinoma (a type of mouth cancer). Nivolumab helps your immune system fight cancer cells.
This trial tests a new way to give an immunotherapy drug called nivolumab before surgery for head and neck cancer. The drug is injected directly into the tumor and is labeled with a fluorescent marker so researchers can see how it works in the removed tissue. This might help improve treatment for future patients.
This trial tests a lower dose of nivolumab (an immunotherapy drug) given less frequently to treat cancers that have spread or cannot be surgically removed. The goal is to see if this approach works well while reducing side effects compared to standard dosing.
This Phase 2 study tests medicines given before surgery for stage III/IV oral squamous cell carcinoma, choosing the treatment based on your tumor marker results. It aims to shrink the cancer and improve outcomes by using two targeted types of therapy.
This trial studies how well two medicines—axitinib and nivolumab—work for people with advanced melanoma that starts in moist “mucosal” areas (like the mouth, nose, throat, or bowel). It may help shrink tumors and control the disease by boosting the immune system and targeting tumor growth.
Hear when a new Premalignant Lesion trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.