Immunotherapy before surgery for mouth cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests an immunotherapy drug called nivolumab given before surgery for mouth cancer. The goal is to see if it can shrink the tumor and improve outcomes after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years old or older.
- You must have a type of mouth cancer called oral squamous cell carcinoma that has not spread to other parts of the body.
- You must be planning to have surgery to remove the cancer as your first treatment.
- You must be generally active and able to care for yourself (ECOG performance status 0 or 1).
- You must not have had radiation or chemotherapy for cancer before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving immunotherapy (sintilimab) together with chemotherapy before surgery can help treat oral cavity cancer. The goal is to shrink the tumor and possibly improve outcomes for patients with early-stage cancer that hasn't spread.
This trial tests a combination of an immunotherapy drug (adebrelimab) and two standard chemotherapy drugs (carboplatin and albumin-bound paclitaxel) before surgery for advanced oral cancer that can be removed. The goal is to see if this approach helps shrink the tumor and improve outcomes.
This trial tests whether adding an immunotherapy drug (sintilimab) to standard chemotherapy before and after surgery can improve outcomes for people with advanced oral squamous cell carcinoma. The treatment is given first to shrink the tumor, then again after surgery to help prevent recurrence.
This trial tests whether adding a type of radiation therapy (SBRT) to chemoimmunotherapy before surgery helps people with advanced mouth or throat cancer. The goal is to see if this combination can shrink tumors more effectively and improve outcomes.
This study tests a specially marked version of a drug called nivolumab (an immunotherapy that helps your immune system fight cancer) given directly into the tumor before your scheduled surgery. The goal is to help researchers see how the drug works in the tumor and whether it could improve treatment for head and neck cancer.
This study tests whether giving an immunotherapy drug called pembrolizumab before surgery can help treat oral cavity cancer. The researchers will look for biomarkers (clues in your tumor) that may predict how well the treatment works.
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