Clin2
NCT06568939Possibly a fitRecruiting

Study of telisotuzumab vedotin for non-squamous lung cancer

Non-Small Cell Lung Cancerc-MET

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial tests a drug called telisotuzumab vedotin (ABBV-399) given through a vein to people with a specific type of advanced lung cancer (non-squamous non-small cell lung cancer) that has a high level of a protein called c-Met. The study aims to see how the drug affects the body and helps control the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
150 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have a type of lung cancer called non-squamous non-small cell lung cancer (NSCLC) that has spread or cannot be removed with surgery.
  • Your cancer cells must have high levels of a protein called c-Met (at least 25% of tumor cells staining strongly).
  • You have tried at least one prior treatment for your advanced lung cancer and it stopped working.
  • You have not had more than one prior type of chemotherapy for your advanced lung cancer.
  • You are able to take care of yourself (ECOG performance status 0 or 1) and are expected to live at least 12 weeks.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06772623Recruiting· Phase 1/Phase 2
Study of telisotuzumab adizutecan plus immunotherapy for advanced lung cancer

This trial tests a new combination treatment for people with advanced non-squamous non-small cell lung cancer who haven't received prior therapy for advanced disease and don't have specific gene changes. The treatment includes an antibody-drug conjugate (telisotuzumab adizutecan) plus an immunotherapy drug (PD-1 checkpoint inhibitor) to see if it helps shrink tumors and improve outcomes.

Phoenix, Arizona
NCT07005102Recruiting· Phase 2/Phase 3
Telisotuzumab adizutecan and osimertinib for EGFR-positive lung cancer

This trial tests a new drug combination (telisotuzumab adizutecan plus osimertinib) as a first treatment for adults with a specific type of advanced lung cancer that has an EGFR mutation. The goal is to see if the combination is safe and works better than standard care.

Chandler, Arizona
NCT04928846Recruiting· Phase 3
Telisotuzumab vedotin vs docetaxel for advanced non-squamous lung cancer

This trial tests an investigational drug (telisotuzumab vedotin) against the standard chemotherapy docetaxel in people with a certain type of non-squamous lung cancer that has high levels of a protein called c-Met. It may offer a new treatment option for those whose cancer has progressed after initial therapy.

Birmingham, Alabama
NCT07155187Recruiting· Phase 2/Phase 3
Study of telisotuzumab adizutecan for EGFR-mutated lung cancer

This trial tests a new drug, telisotuzumab adizutecan (given through a vein), alone or with another targeted therapy, versus standard treatments for people with a specific type of advanced lung cancer that has an EGFR mutation and has gotten worse after previous treatment.

Springdale, Arkansas
NCT05777278Recruiting· Phase 1/Phase 2
Savolitinib plus docetaxel for advanced lung cancer with high MET

This trial studies savolitinib (an oral MET-targeted medicine) combined with docetaxel (an IV chemotherapy) in people with advanced non-small cell lung cancer (NSCLC) whose tumor has high MET activity. It’s designed to see if this combination can shrink tumors or control the cancer after the first standard treatment.

Guangzhou, Guangdong
NCT06930794Recruiting· Phase 3
Study of Vebreltinib Plus Chemo for MET-Positive Lung Cancer

This trial tests a targeted drug (Vebreltinib) combined with standard chemotherapy in people with a specific type of advanced non-squamous lung cancer that has a MET gene change (amplification or overexpression). The goal is to see if this combination works better than chemo alone.

Beijing, Beijing Municipality

Hear when a new Non Small Cell Lung Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.