Can repetitive TMS help with levodopa-induced dyskinesia?
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This study tests whether a non-invasive brain stimulation technique called repetitive TMS can reduce the involuntary movements (dyskinesia) that some people with Parkinson's disease experience as a side effect of their levodopa medication. If you have Parkinson's and bothersome dyskinesia when your medication is working, this trial may be an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of Parkinson's disease.
- You experience involuntary, jerky movements (dyskinesia) when your levodopa medication is working.
- Your Parkinson's medications have been stable for at least 4 weeks.
- You do not have a current psychiatric disorder or take certain medications (like antipsychotics, donepezil, pregabalin, gabapentin, or regular benzodiazepines/opioids).
- You have no other neurological disorders, no personal or close family history of epilepsy or conditions that increase seizure risk.
- You are able to undergo an MRI scan and are not pregnant (if female and of childbearing age).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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