Blood thinners and clot-busting drugs for stroke
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving a clot-dissolving medicine (alteplase or tenecteplase) is safe and effective for people who have had a stroke and are taking a blood thinner (DOAC) like apixaban or rivaroxaban. It aims to see if this treatment can still be given within a few hours of the stroke.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a stroke caused by a blood clot and your doctor says you could get a clot-dissolving drug.
- You took a direct oral anticoagulant (blood thinner) within the last 48 hours, or you are prescribed one but don't know when you last took it.
- Your treatment can start within 4 hours and 30 minutes of when you were last known to be well, or within 4 hours and 30 minutes of waking up with symptoms if an MRI shows the stroke is recent.
- You are 18 years or older.
- You are not pregnant or breastfeeding.
- You do not need a drug to reverse the blood thinner's effect.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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