Clin2
NCT06602011Possibly a fitRecruiting

Triple therapy for advanced liver cancer with bile duct invasion

Hepatocellular Carcinoma

Part of Cancer, Digestive system clinical trials.

This study tests a combination of three treatments—TACE (a procedure that blocks blood flow to the tumor), lenvatinib (a targeted therapy pill), and tislelizumab (an immunotherapy)—for people with liver cancer that has spread into the bile ducts and can't be removed by surgery. The goal is to see if this triple therapy helps shrink or control the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
20 people
Ages
18 years to 75 years
Study type
Observational

Who can take part

  • You are between 18 and 75 years old.
  • You have liver cancer that has spread into the bile ducts and cannot be removed with surgery.
  • You haven't had any cancer treatment (like chemotherapy, immunotherapy, or targeted drugs) for this cancer before.
  • You have at least one tumor that can be seen on a CT or MRI scan and is at least 1 cm across.
  • You are well enough to be up and about (ECOG 0 or 1), have good liver function (Child-Pugh A or B), and your blood counts are normal enough.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05897138Not yet recruiting· Phase 2
Lenvatinib and tislelizumab for advanced liver cancer with hepatitis B

This study tests a combination of two drugs—lenvatinib (a targeted therapy that blocks blood vessel growth) and tislelizumab (an immunotherapy that helps your immune system fight cancer)—in people with advanced liver cancer who also have hepatitis B. The goal is to see if this combination can shrink tumors or slow the cancer's growth, and to find biomarkers (clues in your blood or tissue) that predict who will benefit.

NCT05920863Recruiting· Phase 2
Lenvatinib, immunotherapy, plus liver artery treatment before surgery

This Phase 2 trial tests whether giving lenvatinib and immunotherapy along with TACE (a liver artery treatment) before surgery can lower the risk of hepatocellular carcinoma coming back after surgery. It targets people with certain higher-risk early-stage liver tumors (CNLC IB/IIA).

Hangzhou, Zhejiang
NCT07827807Not yet recruiting· Phase 2
Combining liver-directed therapy with lenvatinib for liver cancer

This trial tests a combination of a procedure that delivers chemotherapy directly to the liver tumor (called TACE) with an oral targeted therapy drug (lenvatinib) for people with liver cancer that cannot be removed with surgery. The goal is to see if this combination can shrink tumors more effectively than TACE alone.

NCT07100405Recruiting
TACE plus Immunotherapy for Advanced Liver Cancer

This trial tests a combination of two treatments for advanced liver cancer: TACE (a procedure that blocks the blood supply to the tumor) and an anti-PD-1 antibody (a type of immunotherapy that helps your immune system fight cancer). The goal is to see if this combination works better than either treatment alone and to understand how it affects the immune system around the tumor.

Shanghai, Shanghai Municipality
NCT06643208Recruiting
Combination therapy for unresectable bile duct cancer

This study tests a combination of liver-directed therapy (D-TACE-HAIC), an immunotherapy drug (Envafolimab), and a targeted therapy pill (Lenvatinib) for people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be surgically removed. The goal is to see if this combination can shrink or control the cancer.

Fuzhou, Fujian
NCT06561399Recruiting
Triple therapy followed by radiation for liver cancer

This trial tests whether adding targeted radiation therapy can help people with liver cancer that cannot be surgically removed. It is for people who have already received a combination of TACE, lenvatinib, and sintilimab and whose tumors have not grown.

Fuzhou, Fujian

Hear when a new Hepatocellular Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.