Clin2
NCT07827807Possibly a fitNot yet recruiting

Combining liver-directed therapy with lenvatinib for liver cancer

Hepatocellular Carcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a combination of a procedure that delivers chemotherapy directly to the liver tumor (called TACE) with an oral targeted therapy drug (lenvatinib) for people with liver cancer that cannot be removed with surgery. The goal is to see if this combination can shrink tumors more effectively than TACE alone.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
20 years and older
Study type
Interventional

Who can take part

  • You are 20 years old or older.
  • You have been diagnosed with liver cancer (HCC) that cannot be surgically removed.
  • You are in generally good health (able to care for yourself and up and about).
  • Your liver function is adequate, as determined by standard blood tests.
  • You have not had any prior systemic (whole-body) cancer treatment for your liver cancer.
  • You have not had any local treatment (like TACE or radiation) in the past 4 weeks.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06740370Recruiting
TACE with lenvatinib and immunotherapy for ruptured liver cancer

This trial tests a combination of targeted therapy (lenvatinib), immunotherapy (PD-1 inhibitor), and a procedure called TACE (which delivers chemotherapy directly to the liver tumor) for people whose liver cancer has ruptured. The goal is to stop bleeding and shrink the tumor.

Beijing, None Selected
NCT05195294Not yet recruiting· Phase 2
Immune cell therapy with or without lenvatinib for advanced liver cancer

This trial tests a special type of immune cell therapy (called HBV-TCR T cells) that is designed to attack liver cancer cells that carry the hepatitis B virus. It may be given alone or combined with a pill called lenvatinib to see if it can shrink tumors and help people with advanced liver cancer.

NCT05920863Recruiting· Phase 2
Lenvatinib, immunotherapy, plus liver artery treatment before surgery

This Phase 2 trial tests whether giving lenvatinib and immunotherapy along with TACE (a liver artery treatment) before surgery can lower the risk of hepatocellular carcinoma coming back after surgery. It targets people with certain higher-risk early-stage liver tumors (CNLC IB/IIA).

Hangzhou, Zhejiang
NCT07408804Recruiting
Lenvatinib alone vs. with chemoembolization for liver cancer

This trial compares the combination of two treatments—chemoembolization (TACE) and lenvatinib—against lenvatinib alone for people with liver cancer that cannot be removed by surgery. It aims to see if the combination works better.

Dhaka
NCT05738616Recruiting· Phase 3
Testing lenvatinib plus TACE and immunotherapy before liver surgery

This study tests whether a combination of the drug lenvatinib, a liver treatment called TACE, and the immunotherapy drug camrelizumab can shrink advanced hepatocellular carcinoma enough to make surgery (or “conversion resection”) possible. It may help some people live longer by improving the chance that the cancer can be removed.

Chengdu, Sichuan
NCT06143579Not yet recruiting· Phase 2
Combination therapy for liver cancer that can be surgically removed

This trial tests a combination of three treatments—chemo given directly into the liver, an oral targeted therapy, and an immunotherapy—for people with liver cancer that could be removed by surgery but isn't the first choice right now. The goal is to see if this combination can shrink the tumor and improve outcomes before surgery.

Hear when a new Hepatocellular Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.