Smetinib capsule for treating type 1 neurofibromatosis
Treatments studied
Part of Brain & nervous system, Cancer, Genetic & congenital clinical trials.
This trial tests a capsule medication (smetinib) for people with type 1 neurofibromatosis (NF1) who have tumors that can be surgically removed but have not spread to vital areas like the brain or spine. The goal is to see if the drug can help shrink or control these tumors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a confirmed diagnosis of NF1 based on official diagnostic criteria.
- A biopsy of your tumor showed it is not a malignant (cancerous) type called MPNST.
- You have at least one measurable tumor that has not invaded the brain or spine and is considered operable.
- You are in generally good health, with adequate blood cell counts, liver, kidney, and heart function.
- You have not taken part in another clinical trial in the last 30 days and are willing to sign a consent form.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new pill (smeitinib) to shrink tumors caused by neurofibromatosis type 1 (NF1). It is for adults with NF1 who have tumors that cannot be removed by surgery, including those that press on the brain or spine.
This trial tests a combination of two targeted drugs (cabozantinib and selumetinib) for people with NF1 who have plexiform neurofibromas that are growing or causing significant problems. The goal is to see if this combination can shrink or slow the growth of these tumors.
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This Phase 2 trial tests HL-085 in adults with neurofibromatosis type 1 (NF1) who have a nerve tumor (plexiform neurofibroma) that cannot be removed by surgery and causes symptoms. It aims to shrink or control the tumor by measuring changes on MRI and monitoring side effects.
This trial tests a low dose of a drug called selumetinib for children with NF1 who have plexiform neurofibromas that cannot be surgically removed. The goal is to see if this drug can help shrink or slow the growth of these tumors.
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