High-dose Furmonertinib for advanced lung cancer after progression
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a higher dose of the targeted therapy Furmonertinib, either alone or with chemotherapy, for people with advanced non-small cell lung cancer that has progressed after initial treatment with a third-generation EGFR inhibitor like Osimertinib or Almonertinib.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced non-small cell lung cancer with an EGFR mutation found on a biopsy or blood test.
- You have previously taken a third-generation EGFR inhibitor (like Osimertinib or Almonertinib) and your cancer has grown while on it.
- You have not had any other cancer treatment since the EGFR inhibitor stopped working.
- You are at least 18 years old, can perform daily activities with little or no help (ECOG 0-1), and have a life expectancy of at least 12 weeks.
- You have at least one tumor that can be measured on scans and has not been treated with radiation before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a targeted pill (furmonertinib) combined with local treatments like radiation or heat/cold to destroy the tumor can help people with early-stage lung cancer that has specific genetic changes (EGFR mutations). It aims to control the cancer without surgery.
This trial tests whether taking furmonertinib before surgery can help shrink tumors in people with early-stage EGFR-mutant lung cancer. It aims to improve surgical outcomes and long-term results.
This trial tests a double dose (160 mg) of a newer targeted pill called furmonertinib for people whose lung cancer has slowly gotten worse while taking osimertinib. It might help control the cancer when the first targeted therapy is starting to lose its effect.
This Phase 2 trial studies furmonertinib alone or with other treatment options to control advanced lung cancer that has specific EGFR gene changes. It may help by targeting the cancer-driving EGFR mutation, especially in people whose mutation is confirmed by a ctDNA blood test.
This trial tests a combination of two targeted drugs, vebreltinib and furmonertinib, for people with advanced non-small cell lung cancer that has an EGFR mutation and high levels of a protein called PD-L1. It may be an option for those who have not yet had treatment for advanced disease.
This trial tests a targeted pill (furmonertinib) to prevent your lung cancer from coming back after surgery. It is for people with a certain genetic change in their tumor (EGFR exon 20 insertion) and stage IB, II, or IIIA disease.
Hear when a new Non Small Cell Lung Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.