Vebreltinib and furmonertinib for advanced EGFR-mutant lung cancer with high PD-L1
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a combination of two targeted drugs, vebreltinib and furmonertinib, for people with advanced non-small cell lung cancer that has an EGFR mutation and high levels of a protein called PD-L1. It may be an option for those who have not yet had treatment for advanced disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have advanced or metastatic non-small cell lung cancer (stage IIIB to IV) that cannot be removed by surgery.
- Your cancer has an EGFR mutation (exon 19 deletion or L858R point mutation) and high PD-L1 (at least 50% by a central lab test).
- You have not had any prior chemotherapy, targeted therapy, or immunotherapy for advanced disease.
- You have not used any EGFR or MET targeted therapy before.
- You are in good overall health (ECOG score 0 or 1).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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