RC48 alone or with envafolimab for advanced prostate cancer with CDK12 changes
Treatments studied
Part of Cancer, Kidney & urinary clinical trials.
This trial tests a drug called RC48, alone or with envafolimab, for men with a specific type of advanced prostate cancer that has not responded to standard treatments. It aims to see if this combination can shrink tumors or slow disease progression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You have advanced prostate cancer that has spread and is resistant to hormone therapy.
- Your cancer has a CDK12 mutation and is HER2 positive (a protein on cancer cells).
- You have had at least one previous hormone therapy and, if recommended, a platinum chemotherapy or PARP inhibitor.
- You have not used HER2-targeted drugs before.
- Your organs (like kidneys, liver, heart) are working well enough as shown by blood and heart tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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