Ultrasound-guided liver pressure measurement for cirrhosis care
Part of Digestive system clinical trials.
This study tests whether using an endoscopic ultrasound to measure the pressure inside blood vessels in the liver can help doctors choose the best treatment for people with advanced liver disease. You may be eligible if you are planning to start a medicine (non-selective beta-blocker) to prevent a first bleed from varices.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with advanced liver disease (such as cirrhosis).
- Your doctor has recommended that you take a medicine called a non-selective beta-blocker (NSBB) to prevent a first bleed from varices (enlarged veins in the esophagus).
- You are 18 years old or older.
- You do not have advanced liver cancer that cannot be treated with a cure.
- You are not pregnant, and you do not have a narrowing in your esophagus that would make the endoscopy difficult.
- Your blood tests show adequate clotting (INR 1.5 or lower) and enough platelets (50,000 or more), and you do not have ascites (fluid in the belly).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase study tests a technique to measure blood pressure changes in people with cirrhosis (scarring of the liver). It may help doctors better understand liver circulation problems and guide safer treatment decisions.
This trial uses a minimally invasive ultrasound technique to directly measure blood pressure in the liver's main vein. It may help doctors decide if patients with severe scarred livers need medication to prevent variceal bleeding.
This trial compares a newer, less invasive method (using an endoscope) to measure pressure in the liver's blood vessels with the standard technique. It may help people with liver disease or suspected cirrhosis better understand their condition.
This study tests a new way to measure if a type of blood pressure medicine called non-selective beta-blockers (NSBBs) is helping patients with cirrhosis. It uses a thin, flexible tube with a camera (endoscope) to measure pressures in the liver and a nearby vein. If you have cirrhosis with high pressure in the portal vein but haven't started NSBBs yet, this study may help your doctor decide if the medicine is working for you.
This study compares a newer, less invasive method using an endoscope (EUS-PPG) with a standard catheter method (HVPG) to measure liver pressure in people with advanced liver disease. The goal is to see if the newer method is equally accurate and safer.
This study checks whether a special ultrasound-guided measurement of blood pressure in your liver can help predict how well endoscopic treatment (banding varices or injecting bleeding sites) will work. It aims to improve outcomes by identifying who is more likely to respond.
Hear when a new Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.