Testing OPT101 for pneumonia with sepsis
Part of Infections, Lungs & breathing clinical trials.
This trial tests a new medicine (OPT101) for people hospitalized with pneumonia and sepsis—where a lung infection causes body-wide inflammation and low oxygen. It aims to help patients who need extra oxygen but are not yet on a breathing machine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are in the hospital with pneumonia that started out in the community (not in a hospital). It has caused trouble breathing, fever, low oxygen, or signs of infection on a chest X-ray.
- You need extra oxygen (like a nasal tube or mask) to keep your oxygen levels normal.
- You are not on a breathing machine (ventilator) or heart-lung bypass (ECMO).
- You do not have active hepatitis B, hepatitis C, HIV, or other active serious infections.
- You are not taking more than 2 immune-suppressing medicines, or have conditions that weaken your immune system.
- You are not allergic to the study medicine OPT101.
- If you could become pregnant, you agree to use effective birth control (like hormonal IUD, condoms, or sterilized partner) during the study and for 30 days after.
- Your weight is under 250 pounds.
- You have not already been in the hospital for more than 72 hours for this pneumonia episode.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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