Shunt device to treat heart failure with preserved ejection fraction
Part of Heart & circulation clinical trials.
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 30 years old.
- You have severe shortness of breath even with daily activities (NYHA class III or IV).
- Your heart's pumping ability is normal or nearly normal (ejection fraction 50% or higher).
- You have been hospitalized for heart failure in the past, or have high NT-proBNP levels, or have signs of diastolic dysfunction on echo, or take diuretics for heart failure.
- A recent heart catheterization shows high pressure inside your heart when resting or exercising.
- You can walk on your own (not wheelchair-bound) and complete a 6-minute walk test.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study is testing better ways to understand and manage heart failure where the heart pumps normally but still doesn't work as well as it should. It looks at people with symptoms like shortness of breath and fatigue, using blood tests and heart imaging to check eligibility.
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
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This trial studies a small implant (an “atrial shunt” device) to improve symptoms and heart function in people with chronic left heart failure that stays active despite standard medicines. It focuses on whether the implant is safe and can help you feel better and possibly breathe easier.
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