Combined pacemaker and stroke prevention study
Part of Heart & circulation clinical trials.
This study tests a new approach that combines a leadless pacemaker with a device to close off a part of the heart (left atrial appendage) to reduce stroke risk in people with atrial fibrillation. It may help patients who need both a pacemaker and stroke prevention.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are over 18 years old
- You have atrial fibrillation
- Your doctor says you need a pacemaker for a slow or irregular heartbeat
- You and your doctor agree that closing off the left atrial appendage is right for you
- You do not have severe mitral valve problems or very weak heart pumping function
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two devices (LAmbre and AMPLATZER Amulet) that are placed in the heart to prevent strokes in people with atrial fibrillation who cannot take blood thinners. If you join, you will be randomly assigned to get one of the two devices.
This trial compares a simpler procedure to the standard one for closing the left atrial appendage in people with non-valvular atrial fibrillation. The goal is to see which approach works better for preventing strokes while lowering bleeding risks.
This trial tests whether combining a pulsed-field ablation (a targeted heart rhythm treatment) with closing off the left atrial appendage can reduce atrial fibrillation risk. It may help people who need rhythm treatment and also want to lower future stroke risk by blocking a common clot-forming spot.
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
This study tests whether closing a heart pocket called the left atrial appendage can lower future stroke or other clot-related events in people with atrial fibrillation. It’s mainly for people who have had a prior clot-related event or are at higher risk but may not be good candidates for long-term blood thinners.
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Hear when a new Leadless Pacemaker trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.