Closing off heart pouch with or without pulsed energy in atrial fibrillation
Part of Heart & circulation clinical trials.
This study tests if adding a special energy treatment (pulsed field ablation) to a standard heart pouch closure is safe and works better for people with persistent atrial fibrillation who have few symptoms but a high risk of stroke.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have had persistent atrial fibrillation for more than 3 months.
- Your atrial fibrillation symptoms are mild (AFEQT score over 70).
- You have a high stroke risk (CHA2DS2-VA score of 2 or more).
- You do not have severe heart failure or a very weak heart pump (LVEF over 35%).
- You have not had a stroke, heart attack, or major bleeding in the last 90 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial combines two procedures at once: a pulsed field ablation to treat atrial fibrillation and a device implant to close the left atrial appendage to reduce stroke risk. It is designed for people in Asia who need both treatments and may benefit from having them together.
This trial tests whether combining a pulsed-field ablation (a targeted heart rhythm treatment) with closing off the left atrial appendage can reduce atrial fibrillation risk. It may help people who need rhythm treatment and also want to lower future stroke risk by blocking a common clot-forming spot.
This trial is for people who need both a special heart treatment called pulsed field ablation (FARAPULSE) and a device to close off a small pouch in the heart (WATCHMAN FLX Pro or WATCHMAN FLX) to prevent strokes. The study will see how well both procedures work when done together.
This trial tests a new type of heart procedure called pulsed field ablation to treat an irregular heartbeat (atrial fibrillation) in people who have already had a device placed to close off a part of the heart (left atrial appendage occlusion). The goal is to see if this safer ablation method can help control your heart rhythm.
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