Closing off heart pouch with or without pulsed energy in atrial fibrillation
Part of Heart & circulation clinical trials.
This study tests if adding a special energy treatment (pulsed field ablation) to a standard heart pouch closure is safe and works better for people with persistent atrial fibrillation who have few symptoms but a high risk of stroke.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have had persistent atrial fibrillation for more than 3 months.
- Your atrial fibrillation symptoms are mild (AFEQT score over 70).
- You have a high stroke risk (CHA2DS2-VA score of 2 or more).
- You do not have severe heart failure or a very weak heart pump (LVEF over 35%).
- You have not had a stroke, heart attack, or major bleeding in the last 90 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares a procedure to close a small pouch in the heart (which is a common source of blood clots causing stroke) to using medications alone in people with atrial fibrillation who cannot safely take blood thinners. The goal is to see if this procedure can reduce stroke risk without the bleeding risks of long-term blood thinners.
This study compares two ways of closing a small pouch in the heart (the left atrial appendage) to help prevent strokes in people with atrial fibrillation (an irregular heartbeat). One method is less invasive, and the study aims to see if it is as safe and effective as the standard approach.
This trial is for people who need both a special heart treatment called pulsed field ablation (FARAPULSE) and a device to close off a small pouch in the heart (WATCHMAN FLX Pro or WATCHMAN FLX) to prevent strokes. The study will see how well both procedures work when done together.
This study tests a device and procedure to close off a small pouch in the heart (left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke, possibly lowering the need for long-term blood thinners.
This trial tests a new method called pulsed field ablation to treat atrial fibrillation (AF), a type of irregular heartbeat. It aims to safely stop AF episodes by targeting specific areas in the heart, and may help people with paroxysmal (coming and going) or persistent AF who haven't had this procedure before.
This trial tests a new type of catheter ablation (using heat to create scar lines in the heart) for people with persistent atrial fibrillation who have a higher risk of stroke or bleeding. It aims to see if this approach can help prevent strokes and reduce the need for long-term blood thinners.
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