Clin2
NCT06712628Worth exploringRecruiting

Comparing how long people stay on upadacitinib vs TNF inhibitors for RA

Moderate to Severe Rheumatoid Arthritis

Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.

This study compares how well people with rheumatoid arthritis stay on two types of medicines: upadacitinib (Rinvoq) and TNF inhibitors. It looks at real-world experiences in Germany to see if one medicine is more likely to be continued over time.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
678 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You have a confirmed diagnosis of moderate to severe active rheumatoid arthritis.
  • Your doctor has already decided to start you on either upadacitinib (Rinvoq) or a TNF inhibitor (like adalimumab, etanercept, etc.) before you learn about this study.
  • You have not taken upadacitinib before.
  • If your doctor is prescribing a TNF inhibitor, you have not taken that specific TNF inhibitor before.
  • You are not currently in another clinical trial with an investigational drug.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07073079Recruiting
Study of upadacitinib and risankizumab for Crohn's after first therapy

This study tests two oral/ injectable medicines (upadacitinib and risankizumab) in adults with moderate-to-severe Crohn's who have already tried a TNF-blocker. It aims to see how well these treatments work in everyday practice.

Castellana Grotte, Bari
NCT07636057Not yet recruiting· Phase 4
Comparing two arthritis pills added to methotrexate

This study compares two oral medications, tofacitinib and upadacitinib, when added to methotrexate for people with rheumatoid arthritis. The goal is to see which one works better and is safer for controlling symptoms.

NCT06581042Recruiting
Study of upadacitinib in adults with IBD in Belgium

This study looks at how adults with Crohn's disease or ulcerative colitis are doing after taking upadacitinib (Rinvoq) for at least 12 months. It helps doctors understand treatment patterns and outcomes in real-world settings.

Bonheiden, Antwerpen
NCT04692493Recruiting· Phase 3
Testing two treatment paths for active rheumatoid arthritis

This Phase 3 study compares two ways to treat active rheumatoid arthritis: a TNF-blocking biologic versus a targeted pill treatment. It may help people who are not doing well on (or cannot tolerate) certain biologic therapies to find a better, more practical option.

Auburn, Alabama
NCT05428488Recruiting· Phase 3
Step-by-step treatment for rheumatoid arthritis with TNF medicine

This trial tests a step-by-step plan for treating rheumatoid arthritis when current medicines aren’t controlling the disease. It compares how well a targeted approach works by adjusting treatment for people who need a TNF inhibitor.

Montpellier, France
NCT07770646Not yet recruiting· Phase 4
Comparing two new treatments for axial spondyloarthritis after a TNF inhibitor fails

This study compares two newer medicines (an IL-17 inhibitor and a JAK inhibitor) for people with axial spondyloarthritis whose previous TNF inhibitor did not work or caused side effects. The goal is to see which one works better for controlling symptoms.

Houston, Texas

Hear when a new Moderate to Severe Rheumatoid Arthritis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.